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References and Links to Papers (#=co-correspondence authors / *=co-first authors)

Cover Illustrations 






















Selected Research Articles:

  1. Wang J et al. Nature Cell Biology (2022)

  2. Yu X, et al. Science Translational Medicine 2021 Sep 29;13(613). (*cover image)

  3. Ahn JH, et al. Nature (2021) 595(7868):591-595. (News and Views at Nat Rev Genet. & NSMB)

  4. Fan H, et al. Nature Genetics (2020) Dec; 52(12):1384-1396. PMID: 33139953.

  5. Zhang Z, et al. Nature 2018 Feb 15;554(7692):387-391.  (News and views at Cancer Discovery)

  6. Cai L, et al. Mol. Cell. 2018 Oct 18;72(2):341-354

  7. Lu R et al. Cancer Cell. 2016; 30(1):92-107.  (*cover image; News & Views at: Cancer Cell & Cancer Dis)

  8. Cai L, et al. Mol. Cell. 2013 Feb 7;49(3):571-82. PMID: 23273982.

Selected Opinions/Review articles:

  1. Zhao S, et al Nature Reviews Cancer. 2021 Jul;21(7):413-430.* PMID: 34002060.  (* With Editor’s cover illustration)

  2. Chi P, et al.  Nature Reviews Cancer. 2010,10(7):457-69. PMID: 20574448.

A Full List of Publications

shuai zhao 2021july 41568_cover_.jpg
SciTransMed WDR5 cover.jpg
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Cover TMM2007 wang.jpg



Liu X*, Wang J*, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai Y, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG$, Baldwin1 AS$, Zhang Q#$. Histone H3 proline 16 hydroxylation regulates mammalian gene expression. Nat Genet. 2022, 54, 1721–1735. PMID: 36347944. $, joint supervision.

Wang J*, Park KS*, Yu X, Gong W, Earp HS, Wang GG#, Jin J#, Cai L#. A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation. Nucleic Acids Res. 2022 Oct 27:gkac861. doi: 10.1093/nar/gkac861. PMID: 36300627


Guo Y#, Wang GG#. Modulation of the high-order chromatin structure by Polycomb complexes. Front Cell Dev Biol. 2022 Oct 5;10:1021658. doi: 10.3389/fcell.2022.1021658. PMID: 36274840


Meng F*, Xu C*, Park KS, Kaniskan HÜ#, Wang GG#, Jin J#. Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. J Med Chem. 2022 Jul 27. doi: 10.1021/acs.jmedchem.2c00807. Online ahead of print.PMID: 35895319

Gao L*, Guo Y*, Biswal M, Lu J, Yin J, Fang J, Chen X, Shao Z, Huang M, Wang Y, Wang GG#, Song J#. Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun. 2022 Jul 22;13(1):4249. doi: 10.1038/s41467-022-31933-w.PMID: 35869095

Herek TA, Bouska A, Lone WG, Sharma S, Amador C, Heavican-Foral TB, Li Y, Wei Q, Jochum D, Greiner TC, Smith LM, Pileri SA, Feldman A, Rosenwald A, Ott G, Lim ST, Ong CK, Song JY, Jaffe ES, Wang GG, Staudt LM, Rimsza LM, Vose J, d'Amore F, Weisenburger DD, Chan WC, Iqbal J. DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T-cells in PTCL-NOS. Blood. 2022 May 31:blood.2021015019. doi: 10.1182/blood.2021015019. PMID: 35639959

Li D*, Yu X*, Kottur J, Gong W, Zhang Z, Storey AJ, Tsai YH, Uryu H, Shen Y, Byrum SD, Edmondson RD, Mackintosh SG, Cai L, Liu Z, Aggarwal AK, Tackett AJ, Liu J, Jin J#, Wang GG#. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022 May 7. doi: 10.1038/s41388-022-02340-8. PMID: 35525905

Quiroga IY*, Ahn JH*, Wang GG#, Phanstiel DH#. Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer. Curr Opin Genet Dev. 2022 Jun;74:101901. PMID: 35427897

Wang J*, Yu X*, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, Jin J#, Wang GG#. EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nature Cell Biol. 2022 Feb 24. doi: 10.1038/s41556-022-00850-x.


Ren Z*, Kim A*, Huang YH, Pi CH, Gong W, Yu X, Qi J, Jin J, Cai L, Roeder RG#, Chen WY#, Wang GG#. A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. Proc Natl Acad Sci. 2022 Mar 1;119(9):e2122940119. PMID: 35217626.

Phanstiel DH#, Wang GG#. Cell type-specific chromatin topology and gene regulation. Trends Genet. 2022 Feb 24:S0168-9525(22)00035-X. doi: 10.1016/j.tig.2022.02.008. PMID: 35221113


​Spangler CJ*, Yadav SP*, Li D*, Geil CN, Smith CB, Wang GG#, Lee T#, and McGinty RK#. DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. Cell Reports 2022 Feb 15;38(7):110369. PMID: 35172132.



Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV#, Bell O#.  Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2021 Oct 26:S2451-9456(21)00437-2. PMID: 34715055

Yu X*, Li D*, Kottur J*, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ, Cai L, Jain R, Liu J, Aggarwal AK, Wang GG#, Jin J#. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Science Translational Medicine. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578. Epub 2021 Sep 29. PMID: 34586829*

*with cover image

Huang YT, Cheng AC, Tang HC, Huang GC, Cai L, Lin TH, Wu KJ, Tseng PH, Wang GG, Chen WY. USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer. Cell Death Dis. 2021 Sep 27;12(10):880. doi: 10.1038/s41419-021-04176-8. PMID: 34580281

Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, Jin J. Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. J Am Chem Soc. 2021 Sep 14. doi: 10.1021/jacs.1c04841. PMID: 34520194


Xu C*, Meng F*, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HÜ#, Jin J#, Wang GG#. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell Chem Biol. 2021 Aug 30:S2451-9456(21)00393-7. PMID: 34469831.


Kim A, Wang GG. R-loop and its functions at the regulatory interfaces between transcription and (epi)genome. Biochim Biophys Acta Gene Regul Mech. 2021 Aug 27:194750. PMID: 34461314

Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH#, Wang GG#. Phase separation drives aberrant chromatin looping and cancer development. Nature (2021) 595(7868):591-595. Epub 2021 Jun 23.* 

   *News and Views at: Nat Rev Genet. 2021 Jul 9 and Nat Struct Mol Biol. 2021 Jul;28(7):543-545.

Zhao S, Allis CD, Wang GG. The language of chromatin modification in human cancers. Nat Rev Cancer. 2021 Jul;21(7):413-430.* PMID: 34002060.     * With Editor’s cover illustration.

Xu C, Tsai YH, Galbo PM, Gong W, Storey AJ, Xu Y, Byrum SD, Xu L, Whang YE, Parker JS, Mackintosh SG, Edmondson RD, Tackett AJ, Huang J, Zheng D, Earp HS, Wang GG#, Cai L#. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic Acid Res. (2021) May 21;49(9):4971- 4988. PMID: 33849067

Ren W*, Fan H*, Grimm SA, Guo Y, Kim JJ, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, Çetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O'Leary SE, Wade PA, Wang GG#, Song J#. DNMT1 reads heterochromatic H4K20me3 to reinforce DNA methylation of transposons. Nature communications. (2021) May 3; 12(1):2490. PMID: 33941775

Fan H*, Guo Y*, Tsai YH, Storey AJ, Kim A, Gong W, Mackintosh SG, Edmondson RG, Li H, Byrum SD, Tackett AJ, Cai L, Wang GG. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic Acid Res. (2021) May 7; 49(8):4441-4455. PMID: 33823544

Li J, Galbo P, Gong W, Storey AJ, Tsai YH, Mackintosh SG, Edmondson RG, Byrum SD, Cai L, Jin J, Tackett AJ, Zheng D, Wang GG. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature Communication. 2021 Feb 16;12(1):1045. PMID: 33594072

Guo Y, Zhao S, and Wang GG. Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction. Trends Genet. (2021) Jun;37(6):547-565.* PMID: 33494958.  * With a cover illustration.


Wang J, Wang GG. No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function. Int J Mol Sci. (2020) Dec 14; 21(24):9501. PMID: 33327550

Fan H*, Lu J*, Guo Y, Li D, Zhang ZM, Tsai YH, Pi WC, Ahn JH, Gong W, Xiang Y, Allison DF, Geng H, He S, Diao Y, Chen WY, Strahl BD, Cai L, Song J#, Wang GG#. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nature Genetics (2020) Dec; 52(12):1384-1396. Nov 2. (online) s41588-020-00729-3. PMID: 33139953.

Koss B, Shields BD, Taylor EM, Storey AJ, Byrum SD, Gies AJ, Washam CL, Choudhury SR, Hyun Ahn J, Uryu H, Williams JB, Krager KJ, Chiang TC, Mackintosh SG, Edmondson RD, Aykin-Burns N, Gajewski TF, Wang GG, Tackett AJ. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer Res. 2020 Oct 1. doi: 10.1158/0008-5472.CAN-20-0524.

Ren W*, Fan H*, Grimm SA, Guo Y, Kim JJ, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Gao L, Cai L, Detrick B, Çetin B, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O'Leary SE, Wade PA, Patel DJ#, Wang GG#, Song J#. Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. PNAS (2020) 117(31):18439-18447. PMID 32675241

Gao L*, Emperle M*, Guo Y*, Grimm SA, Ren W, Adam S, Uryu H, Zhang ZM, Chen D, Yin J, Dukatz M, Anteneh H, Jurkowska RZ, Lu J, Wang Y, Bashtrykov P, Wade PA, Wang GG#, Jeltsch A#, Song J#. Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun. 2020 Jul 3;11(1):3355. PMID: 32620778

Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun. 2020 Jul 3;11(1):3339. doi: 10.1038/s41467-020-17098-4.PMID: 32620764

Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Lu R, Li D, Wang GG, Roeder RG#, Chen WY#. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. Blood. 2020 Jul 2;136(1):11-23. doi: 10.1182/blood.2019003312.PMID: 32276273


Ren W, Lu J, Huang M, Gao L, Li D, Wang GG, Song J. Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. Nat Commun. 2019 Nov 6;10(1):5042. PMID: 31695039.

De Silva D, Zhang Z, Liu Y, Parker JS, Xu C, Cai L, Wang GG, Earp HS, Whang YE. Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. Sci Rep. 2019 Dec 9;9(1):18637. doi: 10.1038/s41598-019-55057-2.

Ren Z*, Ahn JH*, Liu H*, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, Tackett AJ, Jin J, Cai L, Zheng D, Wang GG. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood. 2019 Aug 5. pii: blood.2019000578.

Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O#, Frye SV#. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Aug 14. pii: S2451-9456(19)30244-2.

Lu R, Wang J, Ren Z, Yin J, Wang Y, Cai L, Wang GG#. A model system for studying the DNMT3A hotspot mutation (DNMT3AR882) demonstrates a causal relationship between its dominant-negative effect and leukemogenesis. Cancer Res. 2019 Jul 15;79(14):3583-3594.


Jie L, Ahn JH, Wang GG#. Understanding histone H3 lysine 36 methylation and its deregulation in disease. Cell. & Mol. Life Sciences. 2019 Aug;76(15):2899-2916. (Invited review for a special issue of “Protein Methylation in Cellular Physiology”)


Zhao X*, Ren Y*, Lawlor M*, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J#, Tao J#. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019 May 13;35(5):752-766.e9.


Allison DF, Wang GG. R-loops: formation, function, and relevance to cell stress. Cell Stress 2019; 3 (2), 38-47.


Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS#, Wang GG#. ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Mol Cell. 2018 Sep 28.

Xu B, Cai L, Bulter J, Chen D, Lu X, Joel PS, Rafii S, Zheng D, Wang GG. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 2018 March 13. 10: 1-9. 

Zhang ZM*, Lu R*, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG#, Song J#. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. 2018 Feb 15;554(7692):387-391. 10.1038/nature25477. Epub 2018 Feb 7. With news and comments at Cancer Discovery


Lu R, Wang GG. Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia. Front Oncol., 2017 Oct 12; 7:241. PMID: 29075615



Lu R, Wang GG.  Gene enhancer deregulation and epigenetic vulnerability. Oncoscience, 2016. 3(11-12).

Wu B, Wang Y, Wang C, Wang GG, Wu J, Wan YY#. BPTF Is Essential for T Cell Homeostasis and Function. J Immunol. 2016 Dec 1;197(11):4325-4333. PMID: 27799308


Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D#, Wang GG#. Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene expression program and acute leukemia development.

Cancer Cell. 2016 July 11; 30(1):92-107.*

    *Cover image with News & Views at: Cancer Cell 2016;30(1):9-10; Cancer Discovery  2016;6(8):815. 

Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu JD, Wang GG, Liu J, Qian L. Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming. Cell Stem Cell. 2016 Mar 3;18(3):382-95.

Li Z, Chen P, Su R, Hu C, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, Chen J.  PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease. Cancer Res. 2016 Feb 1;76(3):619-29. PMID: 26747896



Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J.  An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Reports. 2015 Sep 1;12(9):1400-6. PMID: 26299963


Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG.  Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125(2):346-57. PMID: 25395428. PMCID: PMC4287641.


Xu B, Konze KD, Jin J, Wang GG.  Targeting EZH2 and PRC2 dependency as novel anti-cancer therapy. Exp. Hematol. 2015 Aug;43(8):698-712. PMID: 26027790

Wang GG#, Konze KD, Tao JG#. Polycomb Genes, miRNA, and Their Deregulation in B-cell Malignancies. Blood. 2015; 125(8):1217-25. PMID: 25568352. PMCID: PMC4335077.


Gong H, Qian H, Ertl R, Astle CM, Wang GG, Harrison DE, Xu X.   Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain. Oncotarget. 2015; 6(18):15882-90. PMID: 26021816. PMCID: PMC4599244



Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD. NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function. Cancer Discovery. 2014; 4(5):564-77. PMID: 24535671



Cai L*, Rothbart SB*, Lu R*, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J#, Wang GG#.   An H3K36 methylation engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 2013 Feb 7;49(3):571-82. PMID: 23273982.

Lu R, Wang GG. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci. 2013 Nov; 38(11):546-55. PMID: 24035451

Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. An Orally Bioavailable Chemical

Probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8(6):1324-34.




Kumar GS, Chang W, Xie T, Patel A, Zhang Y, Wang GG, David G, Radhakrishnan I. Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. J Mol Biol. 2012 Sep 28;422(4):519-31.


Prior to 2012


Chi P, Allis CD# and Wang GG#.  Covalent histone modifications: mis-written, mis-erased and mis-interpreted in human cancers. Nat Rev Cancer. 2010,10(7):457-69. PMID: 20574448.

Milne TA, Kim J, Wang GG, Wang Z, Ren X, Basrur V, Ruthenburg AJ, Elenitoba-Johnson K, Patel DJ, Roeder RR and Allis CD. Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis. Mol Cell. 2010, 25; 38(6):853-63. PMID: 20541448.


Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, Luo J, Patel DJ and Allis CD. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 2009, 459(7248):847-851. PMID: 20541251.

With News & Views at Nat Rev Cancer 2009(9):461, Nat Chem Biol 2009;5(7):457


Wang Z, Song J, Milne TA, Wang GG, Li H, Allis CD, and Patel DJ. Proline Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression. Cell. 2010, 141(7): 1183-94. PMID: 20541251.

Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A and Hughes SH. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci. 2010,107(7): 3135-40.


Wang GG#, Allis CD#. Misinterpretation of a histone mark is linked to aberrant stem cells and cancer development. Cell Cycle. 2009; 8(13):1982-3. PMID: 19550157


Baker LA, Allis CD and Wang GG. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.  Mutat Res. 2008, 647(1-2): 3-12.  PMID: 18682256


Wang GG, Allis CD# and Chi P#. Chromatin remodeling and cancer: covalent histone modifications. Trends Mol Med. 2007,13(9):363-72.*

  * With editor-selected cover image


Wang GG, Allis CD# and Chi P#. Chromatin remodeling and cancer: ATP-dependent chromatin remodeling. Trends Mol Med. 2007, 13(9): 373-80.


Wang GG, Cai L, Pasillas MP and Kamps MP. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.  Nature Cell Biol. 2007,9(7): 804-812. PMID: 17589499


Wang GG, Calvo KR, Pasillas MP, Sykes DB, Hacker H and Kamps MP. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nature Methods, 2006,3(4): 287-93. *

   * With News and Views at Nat Methods 2006; 3(4): 248 – 249.

Wang GG, Kamps MP. Survival signaling in HoxA9/Meis1 AML. Blood. 2007; 109(9):3619-3620.


Wang GG, Pasillas MP and Kamps MP. Persistent transactivation by Meis1 replaces Hox function in myeloid leukemogenesis models: evidence for co-occupancy of Meis1-Pbx and Hox-Pbx complexes on promoters of leukemia-associated genes.  Mol Cell Biol. 2007, 26(10): 3902-16. PMID: 16648484

Hacker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Hacker G, Mann M and Karin M. Specificity in Toll-like receptor signaling through distinct effector functions of TRAF3 and TRAF6.  Nature. 2006, 439(7073):204-7. PMID: 16306937


Wang GG, Pasillas MP and Kamps MP#. Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.  Blood. 2005, 106(1):254-64.  PMID: 15755900*

  *With Editors' views at Blood 2005; 106(1):6-7.


Wang G, Zhao Y, Liu X, Wang L, Wu C, Zhang W, Liu W, Zhang P, Cong W, Zhu Y, Zhang L, Chen S, Wan D, Zhao X, Huang W and Gu JR#. Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma. Genes Chromosomes Cancer. 2001, 31(3):221-7. PMID: 11391792


Wang G, Huang CH, Zhao Y, Cai L, Wang Y, Xiu SJ, Jiang ZW, Yang S, Zhao T, Huang W and Gu JR#. Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23.  Cell Res. 2000, 10(4): 311-23. PMID: 11191353

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