2019

Ren Z*, Ahn JH*, Liu H*, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, Tackett AJ, Jin J, Cai L, Zheng D, Wang GG#. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood. 2019 Aug 5. pii: blood.2019000578.

Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O#, Frye SV#. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Aug 14. pii: S2451-9456(19)30244-2.

Lu R, Wang J, Ren Z, Yin J, Wang Y, Cai L, Wang GG#. A model system for studying the DNMT3A hotspot mutation (DNMT3AR882) demonstrates a causal relationship between its dominant-negative effect and leukemogenesis. Cancer Res. 2019 Jul 15;79(14):3583-3594.

 

Jie L, Ahn JH, Wang GG#. Understanding histone H3 lysine 36 methylation and its deregulation in disease. Cell. & Mol. Life Sciences. 2019 Aug;76(15):2899-2916. (Invited review for a special issue of “Protein Methylation in Cellular Physiology”)

 

Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J#, Tao J#. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019 May 13;35(5):752-766.e9.

 

Allison DF, Wang GG#. R-loops: formation, function, and relevance to cell stress. Cell Stress 2019; 3 (2), 38-47.

2018

Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS#, Wang GG#. ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Mol Cell. 2018 Sep 28.

Xu B, Cai L, Bulter J, Chen D, Lu X, Joel PS, Rafii S, Zheng D, Wang GG#. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 2018 March 13. 10: 1-9. 

Zhang ZM*, Lu R*, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG#, Song J#. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. 2018 Feb 15;554(7692):387-391. 10.1038/nature25477. Epub 2018 Feb 7. With news and comments at Cancer Discovery

2017

Lu R, Wang GG#. Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia. Front Oncol., 2017 Oct 12; 7:241. PMID: 29075615

2016

 

Lu R, Wang GG#.  Gene enhancer deregulation and epigenetic vulnerability. Oncoscience, 2016. 3(11-12).

Wu B, Wang Y, Wang C, Wang GG, Wu J, Wan YY#. BPTF Is Essential for T Cell Homeostasis and Function. J Immunol. 2016 Dec 1;197(11):4325-4333. PMID: 27799308

 

Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D#, Wang GG#. Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene expression program and acute leukemia development.

Cancer Cell. 2016 July 11; 30(1):92-107.

Cover image with News & Views at: Cancer Cell 2016;30(1):9-10; Cancer Discovery  2016;6(8):815. 

Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu JD, Wang GG, Liu J, Qian L#. Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming. Cell Stem Cell. 2016 Mar 3;18(3):382-95.

Li Z, Chen P, Su R, Hu C, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, Chen J#.  PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease. Cancer Res. 2016 Feb 1;76(3):619-29. PMID: 26747896

2015

 

Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J#.  An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Reports. 2015 Sep 1;12(9):1400-6. PMID: 26299963

 

Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG#.  Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125(2):346-57. PMID: 25395428. PMCID: PMC4287641.

 

Xu B, Konze KD, Jin J, Wang GG#.  Targeting EZH2 and PRC2 dependency as novel anti-cancer therapy. Exp. Hematol. 2015 Aug;43(8):698-712. PMID: 26027790

Wang GG#, Konze KD, Tao JG#. Polycomb Genes, miRNA, and Their Deregulation in B-cell Malignancies. Blood. 2015; 125(8):1217-25. PMID: 25568352. PMCID: PMC4335077.

 

Gong H, Qian H, Ertl R, Astle CM, Wang GG, Harrison DE, Xu X#.   Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain. Oncotarget. 2015; 6(18):15882-90. PMID: 26021816. PMCID: PMC4599244

2014

 

Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD#. NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function. Cancer Discovery. 2014; 4(5):564-77. PMID: 24535671

 

2013

Cai L, Rothbart SB, Lu R, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J#, Wang GG#.   An H3K36 methylation engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 2013 Feb 7;49(3):571-82. PMID: 23273982.

Lu R, Wang GG#. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci. 2013 Nov; 38(11):546-55. PMID: 24035451

Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J#. An Orally Bioavailable Chemical

Probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8(6):1324-34.

 

2012

 

Kumar GS, Chang W, Xie T, Patel A, Zhang Y, Wang GG, David G, Radhakrishnan I#. Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. J Mol Biol. 2012 Sep 28;422(4):519-31.

 

Prior to 2012

 

Chi P, Allis CD# and Wang GG#.  Covalent histone modifications: mis-written, mis-erased and mis-interpreted in human cancers. Nat Rev Cancer. 2010,10(7):457-69. PMID: 20574448.

Milne TA, Kim J, Wang GG, Wang Z, Ren X, Basrur V, Ruthenburg AJ, Elenitoba-Johnson K, Patel DJ, Roeder RR and Allis CD#. Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis. Mol Cell. 2010, 25; 38(6):853-63. PMID: 20541448.

 

Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, Luo J, Patel DJ and Allis CD#. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 2009, 459(7248):847-851. PMID: 20541251.

With News & Views at Nat Rev Cancer 2009(9):461, Nat Chem Biol 2009;5(7):457

 

Wang Z, Song J, Milne TA, Wang GG, Li H, Allis CD, and Patel DJ#. Proline Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression. Cell. 2010, 141(7): 1183-94. PMID: 20541251.

Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A and Hughes SH#. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci. 2010,107(7): 3135-40.

 

Wang GG#, Allis CD#. Misinterpretation of a histone mark is linked to aberrant stem cells and cancer development. Cell Cycle. 2009; 8(13):1982-3. PMID: 19550157

 

Baker LA, Allis CD and Wang GG#. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.  Mutat Res. 2008, 647(1-2): 3-12.  PMID: 18682256

 

Wang GG, Allis CD# and Chi P#. Chromatin remodeling and cancer: covalent histone modifications.* Trends Mol Med. 2007,13(9):363-72.

With editor-selected cover image

 

Wang GG, Allis CD# and Chi P#. Chromatin remodeling and cancer: ATP-dependent chromatin remodeling. Trends Mol Med. 2007, 13(9): 373-80.

 

Wang GG, Cai L, Pasillas MP and Kamps MP#. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.  Nature Cell Biol. 2007,9(7): 804-812. PMID: 17589499

 

Wang GG, Calvo KR, Pasillas MP, Sykes DB, Hacker H and Kamps MP#. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nature Methods, 2006,3(4): 287-93. 

With News and Views at Nat Methods 2006; 3(4): 248 – 249.

Wang GG, Kamps MP#. Survival signaling in HoxA9/Meis1 AML. Blood. 2007; 109(9):3619-3620.

 

Wang GG, Pasillas MP and Kamps MP#. Persistent transactivation by Meis1 replaces Hox function in myeloid leukemogenesis models: evidence for co-occupancy of Meis1-Pbx and Hox-Pbx complexes on promoters of leukemia-associated genes.  Mol Cell Biol. 2007, 26(10): 3902-16. PMID: 16648484

Hacker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Hacker G, Mann M and Karin M#. Specificity in Toll-like receptor signaling through distinct effector functions of TRAF3 and TRAF6.  Nature. 2006, 439(7073):204-7. PMID: 16306937

 

Wang GG, Pasillas MP and Kamps MP#. Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.  Blood. 2005, 106(1):254-64.  PMID: 15755900

With Editors' views at Blood 2005; 106(1):6-7.

 

Wang G, Zhao Y, Liu X, Wang L, Wu C, Zhang W, Liu W, Zhang P, Cong W, Zhu Y, Zhang L, Chen S, Wan D, Zhao X, Huang W and Gu JR#. Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma. Genes Chromosomes Cancer. 2001, 31(3):221-7. PMID: 11391792

 

Wang G, Huang CH, Zhao Y, Cai L, Wang Y, Xiu SJ, Jiang ZW, Yang S, Zhao T, Huang W and Gu JR#. Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23.  Cell Res. 2000, 10(4): 311-23. PMID: 11191353

Publications

References and Links to Papers (#, correspondence author)